Pathophysiological Mechanisms of Migraine and Epilepsy: Similarities and Differences PDF
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Published on 2018 by
Highlights: Migraine and epilepsy are distinct disorders with some clinical and pathophysiological overlaps. Rare genetic forms have allowed the identification of molecular/cellular dysfunctions, disclosing pathological mechanisms. Mutations can target the same protein and neuronal networks, but the type of dysfunction can be disease-specific. Common migraine and common epilepsies are polygenic diseases probably caused numerous different mechanisms. Abstract: Migraine and epilepsy are episodic disorders with distinct features, but they have some clinical and pathophysiological overlaps. We review here clinical overlaps between seizures and migraine attacks, activities of neuronal networks observed during seizures and migraine attacks, and molecular and cellular mechanisms of migraine identified in genetic forms, focusing on genetic variants identified in hemiplegic migraine and their functional effects. Epilepsy and migraine can be generated by dysfunctions of the same neuronal networks, but these dysfunctions can be disease-specific, even if pathogenic mutations target the same protein. Studies of rare monogenic forms have allowed the identification of some molecular/cellular dysfunctions that provide a window on pathological mechanisms: we have begun to disclose the tip of the iceberg.
This Book was ranked at 16 by Google Books for keyword Migraine.
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